Effects of plasmapheresis on the plasma concentration of proteins used to monitor the disease process in multiple myeloma
Wahlin, A.; Grubb, A.; Holm, J.; Marklund, S.L.
Acta Medica Scandinavica 223(3): 263-267
1988
ISSN/ISBN: 0001-6101 PMID: 2451397 DOI: 10.1111/j.0954-6820.1988.tb15796.x
Accession: 005320182
Full-Text Article emailed within 0-6 h
Payments are secure & encrypted
Summary
We studied the influence of plasmapheresis on the plasma concentrations of proteins (IgG, IgA, .beta.2-microglobulin) used for estimation of tumour cell mass in patients with multiple myeloma. Simultaneously, the effects of plasmapheresis on plasma concentrations of proteins (CRP, .alpha.-antitrypsin, haptoglobin) used for the assessment of inflammatory processes were studied. Also, changes in the plasma concentration of protein HC, a recently described protein occurring both as a free protein and as an IgA complex, were studied. The influence of plasmapheresis varied for the different proteins. The plasma levels of IgG, IgA, CRP, .alpha.1-antitrypsin, and haptoglobin decreased during plasmapheresis. The simultaneous reduction of the level of protein HC was smaller than that of IgG, IgA and haptoglobin. The plasma concentration of .beta.2-microglobulin did not decrease during plasmapheresis. The recovery rates of the proteins were found to be approximately inversely related to their molecualr weights.
View