Inhibitory activity of cardio toxin ii of the indian cobra naja naja and certain antibiotics on lysis of bacteria promoted by lysozyme ec 3.2.1.17

Shashidharan, P.; Ramachandran, L.K.; Shashidharan, P; Ramachandran, L.K

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Inhibitory activity of cardio toxin ii of the indian cobra naja naja and certain antibiotics on lysis of bacteria promoted by lysozyme ec 3.2.1.17

Shashidharan, P.; Ramachandran, L.K.

Indian Journal of Biochemistry and Biophysics 20(3): 132-135

1983

ISSN/ISBN: 0301-1208

Accession: 005709520

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Summary

Cardiotoxin II exerted a powerful, but incomplete and irreversible, inhibitory action on the lysis of killed cells of Micrococcus luteus by egg-white lysozyme (N-acetylmuramide glucanohyrolase, EC 3.2.1.17). The antibiotics thiostrepton, a macrocyclic lactone and the antibacterially inactive corresponding open chain compound and polymyxin B acted similarly. The antibiotics gramicidin Dubos, gramicidin S, etamycin, the antibacterially active triformyl derivative of polymyxin and the nearly inactive tetraformyl derivative of polymyxin B did not inhibit lysozyme-induced lysis.

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